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Recurrent abdominal pain or cramps typically related to defecation and associated with change in stool frequency or appearance Changes in stool could include constipation (in constipation-predominant IBS [IBS-C]) or diarrhea (in diarrhea-predominant IBS [IBS-D]) Other symptoms not directly associated with the gastrointestinal tract may include headaches, backaches, lethargy, and anxiety or depression What are the Risk Factors for IBS