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ELF GSH levels have been shown to be inversely correlated with proinflammatory cytokine release both in vitro and in vivo [16, 34]

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Tests involving multiple factors were analyzed using either a three-way analysis of variance (ANOVA) with diet, time, and sex as variables, a two-way ANOVA with diet and time as variables, followed by Sidaks post hoc test, a two-way repeated measures (RM) ANOVA for longitudinal data, followed by Dunnetts post hoc test or by one-way ANOVA followed by Tukeys post hoc test as specified in the figure legends

While the level of evidence for each compound varies, all of them lack the kind of large, well-controlled trials in humans that are necessary to establish safety and effectiveness, which is required for drug approvals