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Pharmacologic GLP-1RA administration has been shown to have various reductions in food consumption scores and an increase in perceived fullness in humans with obesity, where postprandial plasma levels of GLP-1 decreased and peptide YY (PYY) levels increased with the GLP-1RA liraglutide [130]
At its highest dose, 36 mg, participants in a phase 3 trial lost an average of 12.4 percent of their starting weight over 72 weeks
Naltrexone-Bupropion is a combination of a mild inhibitor of dopamine and norepinephrine reuptake (Bupropion) with an agonist of the -opioid receptor (Naltrexone) that acts synergistically to activate pro-opiomelanocortin (POMC) neurons in the hypothalamic, in particular in the neurons in the arcuate nucleus (ARC), resulting in appetite suppression [96, 97]
Sperber, H., et al
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