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According to the researchers, Contrary to reports of increases in suicidal ideation with semaglutide, our analyses revealed a lower risk for both incidence and recurrence of suicidal ideation in patients prescribed semaglutide compared with non-GLP1R agonist anti-obesity and anti-diabetes medications. 20 If you look at the study a little bit deeper there was a decreased risk in [suicidal ideation] in women, men and along every racial group, said Catherine Varney, DO, obesity medicine director for UVA Health and an assistant professor of family medicine at the University of Virginia

But the success of GLP-1 medications has underscored that brain chemistry plays a big role for people who are obese or overweight

Costco in October announced it would sell Wegovy and Ozempic for $499 a month for customers paying cash, and Walmart has rolled out a comparable arrangement with Lilly for Zepbound

Discontinuation or cycling on and off GLP1RAs and tirzepatide might increase long-term cardiovascular risk by promoting variability in weight and HbA 1c