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By utilizing HRs as the effect measure, we ensured greater comparability among studies and enhanced the robustness and stability of the pooled estimate for the association between GLP-1RAs and AUD

This efficiency reflects the designers understanding that the triple receptor profile provides robust efficacy even at the earlier dose levels, allowing for a more streamlined escalation

This article has been updated by The Pharmaceutical Journal team and reviewed by the expert authors to ensure it remains relevant and up to date, following its original publication in December 2025

Clinical trial participation provides free access to pharmaceutical-grade retatrutide with full medical supervision