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The serendipitous discovery of exendin-4 led to the development of exenatide immediate-release (exenatide IR, Byetta), a synthetic version of exendin-4 with C-terminal amidation to enhance its stability [ Figure 2 , Table 1 ], which became the first FDA-approved GLP-1RA in 2005 for the treatment of T2DM in adults [ Table 2 ]

Conclusions: Cere treatment was well tolerated and resulted in significant improvements in the global score two months after the end of active treatment

This blend helps reduce fatigue, improve memory, and support healthy liver function

In a number of our patients hemodialysis was introduced almost immediately after surgery (Zachara et al., 2004c) because of the absence of kidney function