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The NAD+ molecule consists of: Nicotinamide (a derivative of vitamin B3, niacin) Adenine (a purine base, the same as in DNA/RNA/ATP) Two riboses (sugars) A pyrophosphate bridge (two phosphate residues linked together) Chemically, then, NAD+ belongs to the family of dinucleotides together with NADH (the reduced form), NADP+ and NADPH

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It was recently demonstrated that the enzyme kynurenine aminotransferase (KAT) catalyzes the transformation of KYN into KYNA, in a reaction facilitated by the exercise factor PGC-1alpha (207) (Figure 3)

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