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Stable covalent bond with minimal ligand leakage High binding capacity, very low nonspecific binding Scalable Easily adjusts for sample size and automation Reproducible results Investigating protein structure and function Preparing recombinant proteins for X-ray crystallography Ideal for study of protein interactions with protein or DNA Immunization to raise antibodies against a protein of interest Effective screening protein expression even with crude cell lysates Microscale purification of GST-tagged proteins Glutathione-S-transferase (GST) is a highly soluble and stable 26 kDa enzyme that catalyzes the protective mechanisms of Glutathione (GSH)
Its involvement in sleep-associated hormonal rhythms makes DSIP particularly relevant for studying the relationship between circadian biology and endocrine signaling
The HGF/c-Met system also has pro-cognitive effects and is known to be involved in stem cell regulation
Documented adverse events in preclinical models include behavioral hyperactivity, serotonergic overstimulation, and autonomic instability when combining serotonergic peptides with SSRIs or MAOIs at doses previously considered safe independently
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