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For instance, SIRT1 deacetylates carnitine palmitoyltransferase 1A (CPT1A), preventing its ubiquitination and degradation, thereby enhancing FAO and alleviating hepatic steatosis [11]

This tissue distribution is pharmacologically relevant because GLP-1 receptors are expressed not only in the pancreatic islets (where they mediate insulinotropic effects) but also in the gastrointestinal tract (where they slow gastric emptying), the hypothalamus and brainstem (where they mediate appetite suppression), the cardiovascular system (where they may confer cardioprotective effects), and the kidneys (where they promote natriuresis)

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If you're low in them, topping them up helps that machinery work properly