Month 2 Expect changes in appetite and weight
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How Your Genetics Relate to GLP-1 Pathways Several biomarkers should be evaluated before and during semaglutide treatment to contextualize fatigue risk
Importantly, their influence extends to skeletal muscle, where GLP-1 RAs promote glucose uptake via the AMP-activated protein kinase pathway, increase vascular blood flow, and mitigate glucotoxicity, thereby supporting muscle protein synthesis and inhibiting catabolic pathways [14, 15]