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This is a topic that might be top-of-mind if you have SIBO (small intestinal bacterial overgrowth) and/or anything else that is depleting those essential B vitamins

Individual Variability Not everyone experiences side effects equally

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Another RCT found a decrease in homocysteine with 1000 g hydroxo-B12 monthly for 3 months by 2 mol/l, whilst the control group had a 2 mol/l increase, although the difference was not statistically significant