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Freezing causes water molecules in the semaglutide solution to crystallize, potentially damaging the peptide chain and reducing its ability to bind to GLP-1 receptors in your body

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Glucagon-like peptide-1 (GLP-1) receptor agonists aka the -tides, GLP analogs, incretin mimetics *The FDA has approved the use of -glutides to reduce the risk of major cardiovascular events (myocardial infarction, stroke, cardiovascular death) in adults with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors