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Why This Matters in MCAS Many MCAS patients present with: Abdominal pain with hypersensitivity quality Post-prandial flares IBS-like patterns Burning GI discomfort without structural pathology Persistent symptoms despite antihistamines and mast cell stabilizers In these scenarios, symptoms may reflect mast cellnerve cross-talk rather than uncontrolled mediator release alone

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Drink plenty of water throughout the day to support cellular transport and skin hydration