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10.1093/clinids/5.Supplement_3.S407 48 World Health Organization (2021)
In the phase 2 KEYNOTE-942 trial (NCT03897881), the combination of mRNA-4157, a personalized mRNA-based neoantigen vaccine, with pembrolizumab significantly enhanced RFS and DMFS relative to pembrolizumab monotherapy in patients with resected high-risk stage IIIBIV melanoma
Mechanistic investigations revealed OBBs dual regulatory capacity: (i) AMPK hyperphosphorylation-mediated bioenergetic enhancement through UCP1 upregulation, and (ii) inflammation resolution via inhibiting aberrant phosphorylation of IRS-1 coupled with coordinated modulation of immunometabolic signalingsuppressing proinflammatory mediators (MCP-1, CD68, Nos2, CD11c) while activating the downstream protein expression and phosphorylation (PI3K, p-Akt/Akt and p-GSK-3/GSK-3) [215]
