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M.FaircloughJ.et al (2017)

doi: 10.1038/s41467-022-33824-6 122 ThomasCGioielloANoriegaLStrehleAOuryJRizzoGet al

While most clinical evidence supports a favorable safety profile at typical therapeutic doses, caution is warranted as higher doses may cause sedation, cardiovascular effects such as hypotension and arrhythmias, and, in rare cases, respiratory depression

The lawsuit was dropped last week, but highlights the particular tensions facing UHG as it tries to balance financial performance and shareholder obligation with intensifying public and regulatory scrutiny on its business practices