Animal and test-tube studies indicate that they also affect tissue repair and wound healing ( Chapped lips are a common symptom of deficiencies, especially in folate (vitamin B9), riboflavin (vitamin B2), and vitamins B6 and B12 ( People with disorders that affect nutrient absorption such as celiac disease, chronic gastritis, and Crohns disease are especially susceptible to deficiencies ( Given that vitamin B12 is found primarily in animal products, vegans and vegetarians may also be at a higher risk of deficiency ( Furthermore, a deficiency in B vitamins may lead to dermatitis, depression, irritability, and fatigue ( summary Deficiencies in multiple nutrients, including iron, zinc, and B vitamins, can cause chapped lips
Lifestyle interventions: Implement lifestyle modifications, including a healthy diet, regular physical activity, and smoking cessation, to reduce the risk of neuropathy in patients with prediabetes, metabolic syndrome, and T2DM
Gentler alternatives like niacinamide or PDRN have stronger safety profiles in the absence of definitive data and are reasonable substitutes during this window
Chronic use of these medications without concurrent glutathione support may contribute to long-term oxidative stress accumulation and cellular dysfunction
