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J Neurochem 2002

It was also reported that mitochondrial dysfunction can trigger ATF4, and thus, in our case, its activation could be secondary to IFN--mediated disturbance of the TCA cycle and respiratory activity [28]

Doxorubicin, however, shows strong Ames positivity (Toxic, Table 5) and micronucleus induction (Toxic, Table 5), consistent with its DNA intercalation and topoisomerase II inhibitionmechanisms central to both its anticancer efficacy and its risk of secondary malignancies 39