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proposed that weight gain may represent an independent clinical feature of hyperprolactinemia, and reported a markedly increased prevalence of obesity in affected patients ( Consistent with these observations, several case series and retrospective reports have identified unexplained early weight gain, and in some cases, presentation of symptoms in patients later diagnosed with prolactinomas ( In a large retrospective analysis of 219 patients newly diagnosed with pathological hyperprolactinemia, Colao et al