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Effects of prolonged exendin-4 administration on hypothalamic-pituitary-adrenal axis activity and water balance

They reduce food cravings and lead to weight loss

How to manage: Inject in the evening so you sleep through peak nausea Eat smaller, lighter meals avoid fried, fatty, or spicy food Stay hydrated with at least 2.5 L of water daily Rotate injection sites (abdomen, thigh, upper arm) Week 2 Symptoms Stabilise Dose: still 0.25 mg Most patients report nausea has stabilised or begun to ease

Some studies have suggested silymarin may be helpful but it has not been approved and the dose has not been established