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For instance, a large network meta-analysis showed that SGLT-2 inhibitors reduced hospitalization for HF and renal composite outcome more than GLP-1RA [15], and that in patients with cardiovascular disease, SGLT-2 inhibitors show significant reduction in both heart failure (HF) hospitalizations and mortality for patients with HF and reduced ejection fraction [16]

Safety, pharmacokinetics and pharmacodynamics of multiple escalating doses of PEGylated exenatide (PB-119) in healthy volunteers

Whilst some patients report complete loss of interest in sweet foods, others may find that sugar cravings persist or even become more noticeable, particularly if they represent habitual or emotional eating patterns rather than true physiological hunger

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