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10.1074/jbc.M113.479766 16

2016;150:S342S343

A., Werre J

Infertility or recurrent miscarriage [5] Understanding MTHFR Gene Variants Two well-documented MTHFR polymorphisms have significant clinical implications: C677T Variant (rs1801133): Homozygous individuals may experience a 70% reduction in enzyme activity , leading to increased homocysteine levels and an elevated risk of cardiovascular disease, miscarriage, and neural tube defects [4]