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Conversely, NO has a potential cytoprotective mechanism whereby endothelial cells and neutrophils release NO to increase platelet cGMP levels, decrease intracellular free Ca 2+ concentration, and inhibit platelet aggregation and adhesion

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doi: 10.3389/fphar.2024.1437939 Received 24 May 2024 Accepted 03 July 2024 Published 25 July 2024 Volume 15 - 2024 Edited by Marcos Roberto De Oliveira, Federal University of Rio Grande do Sul, Brazil Reviewed by Rosella Abeti, University College London, United Kingdom Andreia Neves Carvalho, University of Lisbon, Portugal Updates Copyright 2024 Mayer, Riera-Ponsati, Kauppinen, Klitgaard, Erler and Hansen