This study has shown that PLGA nanoparticles can exploit lipid raft-mediated pathways for cellular entry, often in a non-specific manner [204]
Current antiviral therapies, primarily nucleoside analogs like acyclovir (ACV) and its derivatives, have critical limitations, including poor central nervous system (CNS) penetration, restricted efficacy against latent infections, associated side effects with the long term medications, and the emergence of ACV-resistant strains [28,29,30,32,33,34]
Tears develop from repetitive overhead motion, acute trauma, or gradual age-related degeneration often a combination of all three
Firstly, altered pharmacokinetics can be observed in older patients due to several shifts in body functions (Winston and Underwood 2015)