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Situations where CJC-1295 would generally be considered inappropriate or high-risk include: Active or prior cancer , given the theoretical role of elevated IGF-1 in tumor growth Diabetes or impaired glucose tolerance , because GH can worsen insulin resistance and raise blood sugar Pregnancy and breastfeeding , where there are no safety data whatsoever Children and adolescents , in whom manipulating the GH axis outside strict medical indications is inappropriate Serious cardiovascular, kidney, or liver disease , which fluid retention and metabolic shifts could aggravate Interactions to consider
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Twice-daily dosing (500mcg morning and evening) shows up in more aggressive protocols but adds cost and injection logistics on top of an already-active TRT schedule
10.1016/j.ejogrb.2017.08.019 10
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