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Should metformin remain the first-line therapy for treatment of type 2 diabetes

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doi:10.1007/s00395-015-0463-z Tsimikas S, Karwatowska-Prokopczuk E, Gouni-Berthold I, et al

However, research protocols often combine them because they synergize to amplify GH pulse amplitude without the appetite stimulation or cortisol elevation seen with earlier secretagogues