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The atrophy of limb skeletal muscles can lead to decreased limb strength, and if respiratory muscles are affected, it may result in respiratory weakness, increasing the risk of severe complications such as pulmonary infections and respiratory failure in critically ill patients (10)

The combination is most commonly used by obesity medicine specialists, not primary care, due to the monitoring required

Additionally, patients should avoid lying down immediately after eating and elevate the head of their bed to prevent nighttime reflux, a common complaint that can disrupt sleep