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Willard, J.D

In the STEP clinical trials, semaglutide 2.4 mg (Wegovy) demonstrated average weight loss of approximately 15% of initial body weight over 68 weeks when combined with lifestyle interventions

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This is particularly relevant for: Short-acting agents (exenatide immediate-release, lixisenatide) May require timing separation from oral medications, particularly those requiring rapid absorption Weekly agents (semaglutide, dulaglutide, exenatide extended-release) Generally have minimal impact on oral contraceptive effectiveness Warfarin/coumarin anticoagulants More frequent INR monitoring may be advised when starting GLP-1 therapy Oral semaglutide (Rybelsus) has specific administration requirements (taking on an empty stomach with a small amount of water) to ensure proper absorption