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Additionally, the reduction in left atrial volume compared to controls suggested a decrease in left atrial pressure after SGLT2i treatment
However, Zepbound's gastrointestinal effectsincluding constipation in 16-17% and diarrhea in 18-24% of patientsmay indirectly increase hemorrhoid risk through straining or anal irritation
This modulation enhances intestinal barrier integrity, reduces endotoxemia, and indirectly alleviates hepatic inflammation and lipid accumulationthus offering an additional axis of protection against NAFLD
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