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Interestingly, while the role of GSTs has classically been associated to the modification of small molecules and the role of glutaredoxins to the deglutathionylation of proteins, it has recently been shown that human GSTO1-1 can deglutathionylate -actin, which should prompt us to consider proteins as GST substrates (Menon and Board, 2013)

These goals require high doses of HGH for optimal results, which can be costly

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The gene was identified in several genome-wide association studies as being important in major depressive disorder