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All the Risks of Prescription GLP-1s May Not Be Known A major study published in 2017 found that nearly 1 out of every 3 drugs approved by the Food and Drug Administration (FDA) have a new safety issues detected in the years after approval. To think we know all the side effects of synthetic GLP-1s right now would be unwise

The challenge facing this strategy is that monotherapies often have varying pharmacokinetics and pharmacodynamics including half-life [69], meaning that the balance of target-receptor agonism may vary over time when using two different agents with varying profiles