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Arch Neurol 2012;69, 836-841

doi: 10.1016/S0002-9149(98)00393-2

For example, p16 ink4a knockout mice exhibited heightened levels of cellular senescence, accompanied by subsequent fibrosis observed in both tubular and interstitial cells, especially within the collecting ducts, after undergoing unilateral ureteral obstruction (Wolstein et al., 2010)

Effect was consistent across subgroups (diabetic and post-surgical)