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The moderately acidic environment can trigger Fe 4 Se 2 W 18 NCs to release Fe 3+ , which can be reduced by GSH to produce Fe 2+ along with the decomposition of H 2 O 2 for OH production, rendering cancer cells more susceptible to oxidative stress (Zhou et al., 2021)

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This can come from general wear-and-tear , where years of use may eventually catch up to you and cause pain that seems to come from out of nowhere, without injury