glp 1 can you stop What happens when taking a GLP-1 medication? In a large Cleveland Clinic study, many patients maintained or continued weight loss. It shows why ongoing support matters. Learn more: https://cle.clinic/4rQEehW What happens after stopping GLP-1

But that average hides important variation

CD31: cell adhesion molecule

In one trial, around 800 people received weekly semaglutide injections accompanied by dietary adjustments, a prescribed exercise regime and psychological counselling, all of which helped them to lose nearly 11% of their starting weight over four months

"Some can maintain on a lower dose, while others require ongoing therapy at their current dose." If you're like me and squeamish about the prospect of weekly injections indefinitely, take note that oral GLP-1s are now on the market: the Food and Drug Administration (FDA) approved oral Wegovy in December 2025 and Foundayo (orforglipron) in April 2026