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This polymorphism has been associated with increased risk of benign prostatic hyperplasia and prostate cancer (Rebbeck et al., 1999) and can be a useful biomarker to identify patients at higher risk for fatal prostate cancer (Agalliu et al., 2006

it stimulates lipolysis without affecting glucose metabolism, which makes it useful when you need to study fat mobilization independent of insulin pathways, but irrelevant for insulin resistance research