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Description

In the HFD/STZ-induced SD rat model, the San-Huang-Yi-Shen Capsule (SHYS) promotes PINK1/Parkin-mediated mitophagy, inhibits the activation of the NLRP3 signaling pathway, attenuates mitochondrial damage, and reduces inflammatory responses, which results in the improvement of DKD [133]

In the SURMOUNT-1 trial , participants receiving the highest dose of Tirzepatide achieved average body weight reductions of 20.9% over 72 weeks, compared to the 14.9% reduction observed with Semaglutide in the STEP-1 trial