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GLP-1/glucagon co-agonists The development of these unimolecular formulations targeting both GLP-1 and glucagon receptors enhances the anorectic effect of GLP-1, provides a lipolytic and lipogenesis-inhibiting effect (Table 2)particularly at the hepatic leveland promotes thermogenic activity, thereby facilitating weight reduction and the treatment of MASLD.1,5,35 Survodutide generates dose-dependent weight reduction of up to 14.9% in 46 weeks.49 It is shown to be effective in reducing liver fat and improving MASH in up to 62% of participants treated with weekly injection of 4.8 mg

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Behav Pharmacol 8 : 607618 Fariello RG, Ferraro TN, Golden GT, Demattei M

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