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If you are someone who hasnt been responding well to your B12 supplements then you may want to consider a trial of B12 shots

doi: 10.1042/bj3610417 15

Active constituents such as harpagoside provide neuroprotection, suggesting indirect benefits in neuroendocrine disturbances associated with thyroid dysfunction (146, 147)

Orthostatic hypotension is a watch-out, especially in older adults on multiple antihypertensives