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Introduction Vitamin D (VD) is an essential nutrient that helps maintain healthy bones [1]

New York: Springer-

An additional effect involves the improvement of deep sleep stages, which are essential periods when the body performs most of its repair and regeneration activities

Specific examples of methylation in detoxification: Arsenic detoxification requires sequential methylation: arsenite to monomethylarsonic acid to dimethylarsinic acid (the excretable form), catalyzed by arsenic methyltransferase (AS3MT) using SAM-e R Mercury undergoes methylation by gut bacteria, converting inorganic mercury to more toxic methylmercury (this is detrimental methylation, not detoxification) R COMT methylation of 4-hydroxy catechol estrogens prevents them from forming reactive quinones that generate ROS and DNA damage R 6