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Studies on healthy adults found that CJC-1295 caused sustained, dose-dependent increases in GH and IGF-1, with no serious adverse effects noted

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Since prior peer-reviewed studies cited above have shown that "long-term administration of PIMO in dogs with asymptomatic MVD is associated with an increase in systolic function and, concomitantly, a progressive worsening of MVD with development of specific mitral valve lesions", this periodic measurement could have predicted (and presumably avoided) the sudden deaths among the pimobendan dogs