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Cys 2 ), cystine-free (Cys 2 -free), or cystine-free/GSH-supplemented (750 M) medium for the indicated timepoints, and cell numbers were determined (n = 2 technical replicates representative of one experiment)

Proc Natl Acad Sci USA 81:50075011 Migoya E, Miller J, Luo W-L et al (2010) Sitagliptin and metformin increase active GLP-1 by complementary mechanisms in treatment-nave patients with type 2 diabetes

The side effects are almost entirely local, not systemic