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MMA is a genetically heterogeneous disorder, with the majority (~60%) of cases caused by complete ( mut 0 ) or partial ( mut ) deficiency of the enzyme methylmalonyl-CoA mutase (MMUT) and the remainder due to errors in the synthesis or transport of 5-deoxyadenosylcobalamin, a vitamin B 12 derivative and essential cofactor of the reaction (1, 2)

doi:10.1136/gut.2006.099929

Indeed, adipocytes are absolutely dependent upon glucose metabolism for the generation of triglycerides

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