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Adjustments dont mean failurethey mean youre working with your biology instead of against it

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The combined primary endpoint of death from cardiovascular disease, nonfatal myocardial infarction, or nonfatal stroke occurred in 569 (6.5%) of patients in the semaglutide group versus 701 (8.0%) of patients in the placebo group, yielding a significant hazard ratio of 0.8 for a 20% relative risk reduction

[5] Afamelanotide is a melanocortin 1 receptor (MC 1 receptor) agonist [1] and a synthetic peptide and analogue of -melanocyte stimulating hormone