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Be honest about your struggles with weight loss (including past diet and exercise attempts), your health concerns related to weight (such as diabetes, hypertension, or joint pain), and your goals, whether its improved overall health, increased energy, or sustainable weight loss

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However, the physiological half-life of GLP-1 in circulation is very short (less than 2 min), which can be attributed to both rapid proteolytic cleavage of the amide bond of alanine at position 8 (Ala8) in the N-terminus by ubiquitous dipeptidyl peptidase IV (DPP-IV), which results in the removal of the two N-terminal amino acids leading to the formation of a truncated inactive form 10,11 and clearance by the kidney as well

It usually means your body is doing a lot of recalibrating behind the scenes