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Additionally, early growth response factor 1 (EGR1) can bind to the promoter region of histone acetyltransferase EP300, upregulate EP300 expression, and enhance histone H3K27 acetylation, thereby inhibiting inflammation and apoptosis of PAECs and alleviating hypoxia-induced PAH (Yang et al., 2023)

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However, based on our results and experience, we call for a careful selection of genotyping methods in the Southeast Asian context

When PSPH knockdown was too strong the additive effect of CQ was only mildly present, as in shPSPH1 GBM cells (Fig