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Evidence for GLP-1 Use in PCOS Management The evidence base for GLP-1 receptor agonists in PCOS management is evolving, with several clinical trials demonstrating promising metabolic and reproductive benefits, though it remains an off-label indication in the UK

Lancet 394, 3950

Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: evidence of several aberrations

The tradeoff: tirzepatide is newer with less long-term safety data than semaglutide, though its profile to date looks equally favorable