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Nat Rev Mol Cell Biol doi

The net cost comparison depends heavily on bioavailability

GSH depletion causes oxidative stress and lipid peroxidation To evaluate the downstream effects of GSH depletion, we measured soluble ROS in RPE cells treated with Cys 2 starvation, BSO, or erastin by flow cytometry using the fluorescent probe H 2 DCFDA

Among primary sites, lung NENs demonstrated the most pronounced benefit (HR = 0.42)