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The neuropsychiatric presentation of Wilsons is the first indication of disease in 4045% of patients older than 20 years of age.2,20 The youngest patient recorded with neurologic onset was 6 years old.2 The symptoms of neurologic involvement of Wilsons are usually related to dysfunction of the basal ganglia, cerebellum, and corticospinal and corticobulbar pathways

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A 2011 in vivo study demonstrated that, in this mouse model, the administration of Pioglitazone induces a proadipogenic antitumor response, with the final result of preventing metastasis and reducing tumor size (Zhang et al., 2017) highlighting the importance of the use of this compound in that specific clinical setting