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There are a few treatments still in the experimental phase which hold future promise for the therapy of HE (Table 3) such as Minocycline, which reduces microglial cell activation in cerebral insult and results in a reduction of brain edema as well as plasma and CSF ammonia levels
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By 48 weeks, significant average weight loss was seen at all maintenance doses: With longer treatment lasting up to 68 weeks, weight loss continued, particularly at higher doses: 12mg: average weight loss of up to 28.7% of body weight This longer-term data shows that weight loss with retatrutide can continue beyond one year, rather than plateauing early, especially at higher maintenance doses
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