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Halford, S

The D-alanine substitution at position 2 is specifically directed at blocking the primary DPP-4 cleavage site, while the remaining substitutions prevent additional enzymatic attack at susceptible positions and reduce oxidative degradation during storage and in vivo

Final Thought: A Canadian Case Study in Market Exclusivity for Innovative Drugs This case study highlights the importance of securing a patent portfolio in Canada to utilize the patent linkage system, and other regulatory tools, to delay entry of generic competitors, which inevitably affects pricing across North America

Front Plant Sci 14:1154571