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Notably, normal rats exhibited a superior sagittal sinus pressure of 24 to 27 mmHg and superior mesenteric pressure and portal pressure of 35 mmHg similar to that of the inferior vena cava, though with values at least 1 mmHg higher in the portal vein

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For semaglutide, there are two maintenance doses (0.5 and 1.0 mg), which were included as covariates to assess the dose dependency of semaglutide exposure

And perhaps even more striking was what happened when treatment stopped: The subjects began overeating almost immediately and regained the lost weight sometimes even more than before